The environment’s impact on antibody yield

The environment has a significant impact on a body's immune system, which in turn dictates how well it can fight pathogens.

Environment-mediated immune suppression results in reduced antibody production. One environmental factor that can trigger immune suppression is chronic stress. The stimuli for triggering chronic stress are for example loud or sudden noises during long periods of time, cramped spaces, isolation and boredom.

Other factors that negatively impact the immune system are the low concentrations of natural microbes in the living space and in diet. This does not challenge and "teach" the immune system how to function properly. This may also trigger allergic reactions and production of antibodies against plastic materials.

Natural day light has many health benefits and also strengthens the immune system. 

Many of these environmental parameters that affect immune suppression are often found in the common super clean animal laboratory facilities that are present today. Interestingly, research shows that these environments do not promote a top-quality antibody product.

The environment makes significant impacts on a body's immune system, which in turn dictates how well it can fight pathogens.

A selection of supporting research literature

1. McEwen, B.S. 1998. Protective and damaging effects of streess mediators: Allostasis and sllostatic load. N. Engl. J. Med. 338, 171-179. 
2. Millan, S. et al. 1996. Short and long restraint differentially affect humoral and cellular immune fuctions. Life Sci. 59, 1431-1442.
3. Dhabhar, F.S., McEwen, B.J. 1999. Enhancing versus suppressive effects of stress hormones on skin immune function. Proc. Natl. Acad. Sci. U.S.A.  96, 1059-1064
4. Fukui, Y. et al. 1997. The restraint stress-induced reduction in lymphocyte cell number in lymphoid organs correlates with the suppression of in vivo antibody production. J. Neuroimmunol. 44, 33-42.
5. Tournier, J.N. et al. 2001. Chronic restraint stress induces severe disruption of the T-cell specific response to tetanus toxin vaccine. Immunology 102, 87-93.